Poster Presentation Clinical Oncology Society of Australia Annual Scientific Meeting 2026

Association between dietary patterns and cardiometabolic health markers in overweight or obese men treated with androgen deprivation therapy: a cross-sectional analysis of the TelEX trial (146446)

Hattie H Wright 1 , Corey Linton 2 , Dennis R Taaffe 3 , Colin Tang 3 4 , Dickon Hayne 5 , Olivia Schumacher 6 , Hao Luo 6 , Anna Maria M Markarian 6 , Rob U Newton 6 , Daniel A Galvão 3
  1. School of Health, University of the Sunshine Coast, Sippy Downs, Qld, Australia
  2. Faculty of Health, Charles Darwin University, Brinkin, NT, Australia
  3. Exercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia
  4. Department of Radiation Oncology, Sir Charles Gairdner Hospital, Perth, WA, Australia
  5. UWA Medical School, University of Western Australia, Perth, WA, Australia
  6. Exercise Medicine Research Institute, Edith Cowan University, Perth, WA, Australia

Aims

To examine the association between dietary patterns and cardiometabolic health markers in overweight/obese men treated with androgen deprivation therapy (ADT).

Methods

A total of 77 overweight/obese men with prostate cancer (body fat ≥ 25%) receiving or previously treated with ADT were recruited into a 6-month exercise and diet intervention. Of those, 65 completed baseline three-day food records analysed in FoodWorks with Dietary Inflammatory Index (DII) and Healthy Eating Index for Australian Adults (HEIFA) derived to examine diet quality. Cardiometabolic markers included anthropometric measures, blood pressure, fasting blood lipids and glucose metabolism biomarkers. Multiple linear regression analysis examined baseline associations between diet quality and cardiometabolic markers, adjusted for age, body mass index and pharmacotherapy (n=61).

Results

Participants were aged 70.1±7.2 years with a BMI of 29.7 (IQR 26.4;32.6) kg/m², waist circumference 101.4±10.8cm, percentage body fat at 31.5±4.5% and 74% (43/58) used cardiometabolic medication. Most (68%) followed an anti-inflammatory diet [(DII=−0.98 (IQR -1.75;0.87)] and average HEIFA score was 60.9/100. HEIFA food component scores were low for vegetables, vegetable variety, fruit, fruit variety, sodium, and saturated fat. DII was associated with LDL-cholesterol and remained significant after adjusting for body fat percentage (r=0.41, p=0.041). In fully adjusted models, HEIFA explained 34.3% of total cholesterol variance (adjusted R²=0.343, F(4,56)=8.85, p<.001,) and 31.7% LDL cholesterol variance (adjusted R²=0.317, F(4,56)=7.97, p=0.005), equating to 0.43 and 0.33 mmol/L lower concentrations per 10-point higher HEIFA score, respectively.

Conclusions

In overweight/obese men receiving or previously treated with ADT, better diet quality was independently associated with lower total cholesterol and LDL-cholesterol, with associations remaining significant after adjustment for adiposity and lipid-lowering therapy. Sodium, saturated fat, and several healthy food group intakes were outside recommendations. Component-level dietary assessment and targeted counselling represent a modifiable adjunct to cardiometabolic risk management in this population.